Table 3. DLPFC Metabolite Levels and Tissue Composition.
| OCD (n=24) | Healthy control (n=22) | 95% CI for difference in means | |
|---|---|---|---|
| MRS metabolite | Mean (SD) | Mean (SD) | |
| Glx/Wa | 3.29 (0.78) × 10−3 | 3.38 (0.77) × 10−3 | −0.37 × 10−3, 0.56 × 10−3 |
| GABA/Wa | 5.34 (1.04) × 10−3 | 5.17 (1.04) × 10−3 | −0.79 × 10−3, 0.45 × 10−3 |
| Tissue composition | Mean percent (SD) | Mean percent (SD) | |
| Cerebral spinal fluid | 16.46 (7.47) | 13.11(6.39) | −7.50, 0.80 |
| Gray matter | 51.42 (5.57) | 51.36 (7.86) | −4.08, 3.96 |
| White matter | 32.13 (5.57) | 35.53 (8.06) | −0.69, 7.49 |
Abbreviations: CI, confidence interval; DLPFC, dorsolateral prefrontal cortex; GABA, γ-aminobutyric acid; Glx, glutamate plus glutamine; OCD, obsessive–compulsive disorder; W, water.
a
Institutional units.