Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2012 Sep 18;19(5):407–422. doi: 10.1093/dnares/dss022

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author 2012. Published by Oxford University Press on behalf of Kazusa DNA Research Institute.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

PMC Copyright notice

Figure 4. — Expression profiles of the genes within cluster 65. (A) The mean expression profile of the probe set intensities within cluster 65 over the 130 samples. The red-boxed area indicates the Peyer's patch M cell data sets; the blue-boxed area indicates the FAE data sets. The cluster 65 nodes derived from the network graph are also shown. (B) Heat map showing the mean expression of all probe sets within cluster 65 in samples from enriched Peyer's patch M cells (PP M cells), CT-stimulated villous epithelium (CT-stim. villous epith.), ileum epithelial cells (ileum IEC), FAE, SI epithelium (SI epith.), ileum and NALT. Each column represents the mean (log₂) probe set intensity for all samples from each source (n = 2–4). P-values for those genes which were expressed significantly within the FAE at levels >2.0-fold when compared with the villous epithelium (ileum IEC, SI epithelium, ileum) are indicated. (C) IHC confirmation of the expression of proteins encoded by FAE-related genes (CCL20 and ubiquitin D, red) and M cell-related (GP2⁺ cells, green, arrows) in mouse Peyer's patches. SED, subepithelial dome. Dotted line indicates the luminal surface of the FAE.