Table 4. Toxicities and overall treatment time in relation to different treatment approaches.
| Treatment |
Acute toxicity |
Late toxicity |
OTT of CRT |
|||||||||||||||
| Categories | No. | Skin |
Mucosa |
Xerostomia | Fibrosis of the neck | Loss of taste | Bone problems | Dysphagia | Teeth problems | Median (range) in days | ||||||||
| G0 | G1 | G2 | G3 | G4 | G0 | G1 | G2 | G3 | G4 | |||||||||
| RT | 18 | 3 | 8 | 6 | 1 | 0 | 0 | 0 | 1 | 17 | 0 | 7 | 3 | 3 | 1 | 1 | 0 | 49 (40–53) |
| CRT | 10 | 1 | 6 | 3 | 0 | 0 | 0 | 0 | 3 | 7 | 0 | 6 | 1 | 3 | 0 | 0 | 1 | 51 (30–54) |
| Surgery→RT | 23 | 1 | 13 | 5 | 4 | 0 | 0 | 0 | 4 | 19 | 0 | 10 | 2 | 1 | 2 | 0 | 0 | 46 (13–53) |
| Surgery→CRT | 7 | 0 | 5 | 2 | 0 | 0 | 0 | 0 | 2 | 5 | 0 | 2 | 0 | 0 | 0 | 0 | 1 | 46 (37–51) |
| ICT→RT | 2 | 0 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 46 (46–46) |
| ICT→CRT | 18 | 2 | 10 | 6 | 0 | 0 | 0 | 0 | 3 | 14 | 1 | 9 | 1 | 4 | 0 | 1 | 1 | 50 (36–54) |
| All | 78 | 7 | 44 | 22 | 5 | 0 | 0 | 0 | 13 | 64 | 1 | 34 | 7 | 11 | 3 | 2 | 3 | 48 (13–54) |
IMRT, intensity-modulated radiotherapy; CRT, concurrent chemotherapy and IMRT; ICT, induction chemotherapy; OTT, overall treatment time; RT, radiotherapy.