Table 2. Influence of hippocampal sparing and dose optimisation in terms of relative risk for brain metastases at 3 years with a prescription dose of 25 Gy.
| Hippocampal sparing? | Optimised doses? | Maximal reseeding |
Neglecting reseeding |
|||
| Average prev | Worst prev | Average prev | Worst prev | |||
| No | Yes | Optimal cerebellar dose (Gy) | 34.9 | 31.4 | 39.8 | 34.5 |
| Optimal cerebral dose (Gy) | 23.7 | 24.2 | 23.1 | 23.8 | ||
| Change in RR compared with uniform dose | −0.90% | −0.40% | −1.35% | −0.50% | ||
| Yes | Yes | Optimal cerebellar dose (Gy) | 35.0 | 31.8 | 40.0 | 35.1 |
| Optimal cerebral dose (Gy) | 23.7 | 24.1 | 23.0 | 23.7 | ||
| Change in RR compared with uniform dose | 0.10% | 3.50% | −0.70% | 1.85% | ||
| Change in RR owing to dose optimisation | −0.90% | −0.40% | −1.30% | −0.57% | ||
| Yes | No | Change in RR compared with uniform dose | 1.00% | 3.90% | 0.60% | 2.42% |
prev, prevalence; RR, relative risk.