Table 2. Comparison of HP, LW, MW and mTDR for their ability to distinguish advanced disease from limited disease (ROC analysis).

Measurement methoda	Criterion	Sensitivity (%)	Specificity (%)	AUC	p-Valueb
HP	≥2.8 cm	62	63	0.64	0.14
LW	≥2.8 cm	69	63	0.65	0.10
MW	≥2.1 cm	75	74	0.74	0.01
mTDR	≤0.13	69	89	0.82	0.001

^aTumour size determined by histopathology (HP) on CT lung window (LW) or on CT soft-tissue/mediastinal window (MW); mTDR, modified tumour shadow disappearance rate = (1 – [MW/LW]). ^bTest for null hypothesis: true area = 0.5. AUC, area under the receiver operating characteristic (ROC) curve.