Table 3. Comparison of HP, LW, MW and mTDR for their ability to distinguish advanced disease from limited disease in patients with tumours ≤3 cm (ROC analysis).

Measurement methoda	Criterion	Sensitivity (%)	Specificity (%)	AUC	p-Valueb
HP	≥1.65 cm	86	47	0.65	0.25
LW	≥1.95 cm	71	53	0.69	0.15
MW	≥1.35 cm	86	41	0.73	0.08
mTDR	≤0.20	71	94	0.82	0.017

^aTumour size determined by histopathology (HP) on CT lung window (LW) or on CT soft-tissue/mediastinal window (MW); mTDR, modified tumour shadow disappearance rate = (1–[MW/LW]). ^bTest for null hypothesis: true area = 0.5. AUC, area under the receiver operating characteristic (ROC) curve.