Figure 1.
Epidermal cell death scores in (a) high dose broad-beam (BB) and (b) low dose BB and microbeam radiotherapy (MRT)-irradiated mouse skin tissue for different doses and times. (c) Score 1 (arrows show apoptosis) in 400 Gy MRT 5 days post-irradiation. (d) Score 3 (full thickness epidermal necrosis) in 400 Gy BB 5 days post-irradiation. Necrosis was not confined to the epithelial cells in the epidermis; we also observed ulceration extending to almost half the dermal depth in mice in the high dose BB group by day 5. The graphs in Figure 1 (and subsequent plots) contain connecting lines to aid visualisation only. The scoring data at the different time-points are from different mice. Error bars are standard error of the mean (SEM).