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. 1982 Dec;79(23):7598–7602. doi: 10.1073/pnas.79.23.7598

Opiates and classical conditioning: selective abolition of conditioned responses by activation of opiate receptors within the central nervous system.

M D Mauk, J Madden 4th, J D Barchas, R F Thompson
PMCID: PMC347388  PMID: 6296841

Abstract

It has previously been shown that opiates produce selective abolition of aversively motivated classically conditioned responses in the rabbit. The experiments reported here show that these effects are mediated by specific activation of opiate receptors within the central nervous system in that this central activation is both necessary and sufficient to produce opiate-induced abolition of conditioned responding. Further characterization suggests that selective activation through opiate-mu-receptor interactions within the periaqueductal gray/periventricular region of the fourth ventricle may be critical in mediating this abolition.

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Selected References

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