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11C-methionine positron emission tomography (PET). After application of radiolabelled amino acids, they are transported through endothelial cells into the tumour. Background uptake in brain is limited, enabling the delineation of the glioma. This is a clear advantage over 18F-fluorodeoxyglucose PET. Owing to metabolisation of methionine, quantification of uptake is only possible in a semi-quantitative manner (tumour-to-background ratios).
