Figure 3.
11C-methionine positron emission tomography (MET-PET) for imaging-guided chemotherapy. A patient with an anaplastic oligoastrocytoma after resection and radiation therapy presented with increased seizure activity as sign of tumour recurrence. Based on MRI (upper left) a clear indication of active tumour could not be found. 11C-MET-PET identified recurrent tumour (lower left). The patient was put on temozolomide treatment. Follow-up 11C-MET-PET could identify positive temozolomide (TMZ) response (lower row) whereas MRI did not show a clear change over time (upper right) (modified from Galldiks et al [63] with permission). CTX, chemotherapy; OA, oligoastrocytoma; OP, operation; RTX, radiotherapy.