Figure 5.

Parametric mapping of ¹⁸F-3′-deoxy-3′-fluorothymidine (FLT) Ki (a) and correlation to Ki-67 (b). (a) Coregistered ¹⁸F-FLT positron emission tomography (PET), ¹¹C-methionine (MET)-PET, parametric map of ¹⁸F-FLT Ki and MRI (T₁+Gd) in a 63-year-old patient with a first diagnosed glioblastoma multiforme. ¹⁸F-FLT- and ¹¹C-MET-PET images show high tracer uptake ratios (¹⁸F-FLT, 6.7-fold; ¹¹C-MET, 3.2-fold) than the contralateral tissue, parametric ¹⁸F-FLT mapping shows an increased kinetic metabolic rate constant Ki (0.0161 ml g^–1 min^–1) which is related to a high percentage Ki-67 expression (45%). (b) The relationship between ¹⁸F-FLT Ki and Ki-67 expression in 11 patients with newly diagnosed glioma (modified from Ullrich et al [79] with permission).