Table 2.

Uncertainty factors used in the derivation of risk metrics for OTA from the 90-day pig study.

	EFSA (2006)a Lowest dose tested: 8 µg kg bw−1 day−1	Health Canadaa Derived benchmark dose: BD10 = 1.56 µg kg bw−1 day−1
Source of uncertainty:
Intraspecies	10	10
Interspecies	15b	25c
LOAEL to NOAEL	3
90-Day subchronic to chronic		2
Overall uncertainty	450	500
Resulting TDI (ng kg bw−1 day−1)	17	3.0

Notes: ^aUncertainty factors applied to lowest dose tested (8 µg OTA kg bw⁻¹ day⁻¹)orBD₁₀ (data from Krogh et al. 1974).

^bToxicodynamics (2.5x); toxicokinetics related to OTA half-life (6x) as estimated by EFSA.

^cToxicodynamics (2.5x); toxicokinetics related to OTA half-life (10x) (see Table 3).