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. 2012 Sep 5;32(36):12337–12348. doi: 10.1523/JNEUROSCI.2129-12.2012

Figure 3.

Figure 3.

The α7 nAChR-mediated LTP involves prolonged calcium activity enhancement in both presynaptic and postsynaptic sites in septohippocampal slice cocultures. LTP was induced by pairing SO pathway 100 ms before SC pathway in septohippocampal slice cocultures. A, Normalized SC pathway stimulation-induced postsynaptic GCaMP3 responses showing the prolonged enhancement of postsynaptic calcium activities after the SO pathway pairing protocol. SC pathway was stimulated at the time point of 0 s as indicated by the arrow. B, Images of SC pathway-induced postsynaptic calcium imaging from different time points before or after pairing protocol. C, Normalized presynaptic GCaMP3 responses showing the prolonged enhancement after the SO pathway pairing protocol. D, Images of presynaptic calcium imaging from different time points before or after pairing protocol. E, Bar graph showing the prolonged postsynaptic (Post) and presynaptic (Pre) responses during LTP; both were abolished in α7 nAChR knock-out slices. *p < 0.01, **p < 0.001, as compared with before pairing, Student's t test, n = 6 in each group. Ssc, Stimulation of the SC; WT, wild type.