Table 1.
Proteins Susceptible to Glutathionylation and Effects of This Modification on Apoptosis
| Protein | Challenge to induce glutathionylation | Effect on protein | Apoptosis or survival | References |
|---|---|---|---|---|
| Fas | Grx knockdown | Activation | Apoptosis | (3) |
| Pro-caspase-3 | Grx knockdown | Inhibition | Survival | (76) |
| Ras | Mechanical strain or angiotensin II | Activation | Apoptosis | (1,77) |
| PTEN | ATP-induced ROS | Inhibition | Survival | (20) |
| PKC | Diamide and GSH | Inhibition | Apoptosis | (15,108) |
| MEKK | H2O2 | Inhibition | Apoptosis | (19,41) |
| c-Jun | GSSG | Inhibition | Apoptosis | (52,53,109) |
| NFκB | ROS or N-acetyl Cys | Inhibition | Apoptosis | (28,80,81) |
| IKKβ | Grx knockdown or H2O2 | Inhibition | Apoptosis | (82) |