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p53 is important in maintaining both basal and induced levels of Nrf2. (A) HCT116 p53+/+ and p53−/− cells were treated with etoposide for 24 h and subjected to immunoblot analysis. (B) Wild-type or p53-deficient mice (n=3) were treated with 300 mg/kg BHA for 12 h through intraperitoneal injection. Liver tissues were subjected to immunoblot analysis.
