Table 1. Pharmacokinetic Parameters of SB-3CT and Compound 2 after a Single i.p. Dose to Female Mice.

	SB-3CT after dose of SB-3CT		compound 2 after dose of SB-3CT		compound 2 after dose of compound 2
parameter	brain	plasma	brain	plasma	brain	plasma
AUC0–lasta	118	174	2.61	1.25	82.8	120
AUC0–∞a	122	179	3.31	1.65	82.8	121
t1/2α (min)	4.8	6.9	8.8	5.4	4.2	4.2
t1/2β (min)	46	22	94	78	29	31
brainAUC/plasmaAUC	0.68		2.0		0.68

^aAUC in pmol·min/mg for brain and in μM·min for plasma.