Table 2. Regional Brain Distribution of SB-3CT and Compound 2^a.

	SB-3CT after dose of SB-3CT		compound 2 after dose of SB-3CT		compound 2 after dose of compound 2
	concb	ratioc	concb	ratioc	concb	ratioc
whole brain	5.0 ± 0.8	0.78 ± 0.13	0.054 ± 0.009	0.96 ± 0.23	6.1 ± 0.9	0.66 ± 0.14
brain stem	4.2 ± 0.8	0.66 ± 0.13	0.059 ± 0.004	1.1 ± 0.2	5.8 ± 0.6	0.63 ± 0.11
cerebellum	3.1 ± 0.5	0.48 ± 0.08	0.050 ± 0.008	0.89 ± 0.17	4.9 ± 0.6	0.53 ± 0.10
cortex	3.6 ± 0.6	0.56 ± 0.10	0.061 ± 0.027	1.1 ± 0.5	4.9 ± 0.7	0.53 ± 0.11
hippocampus	3.9 ± 0.6	0.61 ± 0.10	0.035 ± 0.003	0.63 ± 0.12	5.4 ± 0.5	0.59 ± 0.10
striatum	4.6 ± 0.3	0.72 ± 0.06	0.045 ± 0.008	0.80 ± 0.20	5.6 ± 0.8	0.61 ± 0.12
plasma	6.4 ± 0.3		0.056 ± 0.010		9.2 ± 1.3

^aRegional brain distribution determined at 10 min after i.p. dose of SB-3CT or compound 2 to female mice; 9 mice were dosed and brain regions pooled from 3 mice.

^bConcentrations in pmol/mg tissue for brain and in μM for plasma.

^cRatio of the concentration in brain region to plasma.