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. 2012 Aug 3;3(10):744–752. doi: 10.1021/cn3000372

Figure 2.

Figure 2

Properties of CD.siRNA complexes. (a) CD.siRNA binding was shown by gel electrophoresis. Fluorescent bands correspond to 100 bp DNA ladder (L), free siRNA and unbound siRNA. (b) Z-Ave (size (nm)) and zeta potential (charge (mV)) of CD-siRNA complexes at increasing mass ratios (MR; μg CD/μg siRNA) were measured in DIW (final siRNA concentration 3 μg/mL) using dynamic light scattering (Malvern ZetaSizer Nano). (c) Serum degradation assay, as shown by gel electrophoresis. Uncomplexed siRNA or CD.siRNA was exposed to 50% serum for up to 24 h. CD at least partially protected siRNA from degradation.