Table 2.
Table 2a ABO blood group and risk of ovarian cancer in 8 studies from the Ovarian Cancer Association Consortium | |||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Blood group | MAYa | NCOa | NECb | NHSc | POLa | TBOa | TORa | UKGd | meta-analysisf | ||||
| |||||||||||||
OR | OR | OR | OR | OR | OR | OR | OR | Cases (N) | Controls (N) | OR | (95% CI) | p | |
O | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 2222 | 2987 | 1.00 | (ref.) | |
A | 1.21 | 1.04 | 1.10 | 0.92 | 1.03 | 1.67 | 1.23 | 1.07 | 2286 | 2865 | 1.09 | (1.01–1.18) | 0.03 |
B | 0.95 | 1.21 | 1.26 | 0.89 | 0.66 | 1.59 | 1.14 | 0.93 | 529 | 732 | 1.03 | (0.88–1.20) | 0.76 |
AB | 0.78 | 1.13 | 1.03 | 1.48 | 0.86 | 0.69 | 1.28 | 1.21 | 195 | 253 | 1.09 | (0.89–1.33) | 0.40 |
Table 2b ABO diplotype and risk of ovarian cancer in 8 studies from the Ovarian Cancer Association Consortium | |||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Diplotype | MAYa | NCOa | NECb | NHSc | POLa | TBOa | TORa | UKGd | meta-analysisf | ||||
| |||||||||||||
OR | OR | OR | OR | OR | OR | OR | OR | Cases (N) | Controls (N) | OR | (95% CI) | p | |
O/O | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 2222 | 2987 | 1.00 | (ref.) | |
A/O | 1.35 | 0.98 | 1.14 | 0.95 | 0.95 | 1.71 | 1.26 | 1.09 | 1912 | 2363 | 1.11 | (1.01–1.22) | 0.03 |
A/A | 0.67 | 1.37 | 0.93 | 0.74 | 1.36 | 1.58 | 1.09 | 0.99 | 374 | 502 | 1.03 | (0.87–1.21) | 0.76 |
B/O | 0.95 | 1.15 | 1.23 | 0.88 | 0.67 | 1.69 | 1.17 | 0.95 | 495 | 681 | 1.09 | (0.88–1.19) | 0.73 |
B/B | 0.94 | 2.85 | 1.76 | 0.96 | 0.61 | NAe | 0.89 | 0.53 | 34 | 51 | 0.98 | (0.61–1.56) | 0.92 |
A/B | 0.78 | 1.13 | 1.03 | 1.48 | 0.86 | 0.69 | 1.28 | 1.21 | 195 | 253 | 1.09 | (0.89–1.33) | 0.40 |
Adjusted for age
Adjusted for age and study phase
Adjusted for age, DNA source (blood vs. cheek) and cohort (NHS vs. NHSII)
Unadjusted
There were no cases with the BB diplotype.
Results were combined using random-effects meta-analysis; all p-heterogeneity across studies were >0.20