Table 2.

Hematological and Nonhematological Toxicity in Common Terminology Criteria for Adverse Events, Version 4.0

Reaction	Grade 1	Grade 2	Grade 3	Grade 4	Grade 5
Neutropenia	Neutrophils < LLN–1,500/mm3 < LLN to 1.5 × 109/L	Neutrophils < 1,500–1,000/mm3 < 1.5 to 1.0 ×109/L	Neutrophils < 1,000–500/mm3 < 1.0 to 0.5 × 109/L	Neutrophils < 500/mm3 < 0.5 × 109 /L	Death
Febrile neutropenia*	—	—	—	Life-threatening consequences (e.g., septic shock, hypotension, acidosis, necrosis)	Death
Hypersensitivity or allergic reaction	Transient flushing or rash Drug-induced fever < 100.4°F (38°C)	Rash Flushing Urticaria Dyspnea Drug-induced fever > 100.4°F (38°C)	Symptomatic bronchospasm with or without urticaria requiring parenteral medications Allergy-related edema, angioedema, hypotension	Anaphylaxis	Death
Diarrhea	Increase of less than four stools per day over baseline Mild increase in ostomy output compared with baseline	Increase of 4 to 6 stools per day over baseline IV fluids indicated for < 24 hours Moderate increase in ostomy output compared with baseline Does not interfere with ADL	Increase of 7 or more stools per day over baseline Incontinence IV fluids indicated for 24 hours or more Hospitalization Severe increase in ostomy output compared with baseline Interferes with ADL	Life-threatening consequences (e.g., hemodynamic collapse)	Death

ADL = activities of daily living; ANC = absolute neutrophil count; LLN = lower limit of normal.

^*Fever of unknown origin without clinically or microbiologically documented infection; ANC < 1.0 × 10⁹/L and fever ≥ 38.5°C.

Data compiled from National Institutes of Health.³⁵