Table 3.

Suggested Cabazitaxel Dose Modifications for Hematological and Nonhematological Toxicities

Hematological	Recommended Dose Adjustment for Toxicity
Neutropenia ≥ grade 3 for more than 1 week despite prophylaxis with G–CSF	Delay treatment until ANC > 1,500/mm3; then reduce dose to 20 mg/m2 with continued secondary WBC growth factor prophylaxis.
Febrile neutropenia	Delay treatment until improvement/resolution and ANC > 1,500/mm3; then reduce dose to 20 mg/m2 with continued secondary WBC growth factor prophylaxis.
Persistent hematological toxicity despite dose reduction	Discontinue treatment.
Nonhematological	Recommended Dose Adjustment for Toxicity
Severe hypersensitivity reaction	Discontinue treatment immediately.
Diarrhea ≥ grade 3 or persistent despite appropriate medications, fluids, and electrolyte replacement	Delay treatment until improvement or resolution; then reduce dose to 20 mg/m2 .
Persistent diarrhea despite dose reduction	Discontinue treatment.

ANC = absolute neutrophil count; G–CSF = granulocyte–colony-stimulating factor; WBC = white blood cell.

From Jevtana (cabazitaxel) prescribing information.²⁰