Table 1.
Cell type | RKA182 | FBEG100 | ARS | Deoxy-ARS |
---|---|---|---|---|
HL-60 | 11.6 ± 4.0a | 40.6 ± 3.0 | 2.2 ± 0.2 | >100 |
HEK293T | 14.7 ± 0.2 | 37.1 ± 2.5 | 20.1 ± 3.4 | >100 |
HepG2 | 25.5 ± 5.3 | 58.8 ± 10.8 | 77.2 ± 17.2 | >100 |
HeLa | 37.7 ± 5.5 | 55.2 ± 5.6 | 87.8 ± 11.4 | >100 |
RBC | 28.0 ± 7.3 | >100 | 18.9 ± 3.7 | >100 |
PBMC | 46.6 ± 0.7 | 56.8 ± 2.1 | >100 | >100 |
P. falciparum (3D7) | 4.9 ± 1.2 nmol/Lb,c | 1.4 ± 0.3 nmol/L | 1.8 ± 0.6 nmol/Lc | ND |
ND, not determined.
IC50 values (μmol/L) were calculated from ATP assay concentration-response curves (Supplementary Figure S3) following incubation with the indicated compound for 24 h. Data represent mean ± SD, n = 3.
In vitro antimalarial activities were calculated against the chloroquine-sensitive 3D7 strain of P. falciparum.
See reference (16).