Table 1.
Comparison of selected characteristics of adults with type 2 diabetes randomized in various studies.
| Measure | UKPDS [UK Prospective Diabetes Study (UKPDS) Group, 1998a, 1998b] |
ADVANCE [Patel et al. 2008] |
ACCORD [Gerstein et al. 2008] |
|---|---|---|---|
| N randomized | 3867 | 11,140 | 10,251 |
| Source population | UK | 20 nations (no USA) | USA, Canada |
| Age (mean) | 53.3 years | 66 years | 62.2 years |
| Duration diabetes mellitus at randomization | 4 Years | 8.0 Years (mean) | 10 Years (median) |
| Years and mean f/u | 10 years median | 5 years median | 3.5 years mean |
| Baseline A1c (mean ± SD) | 7.1% ± 1.51% | 7.51% ± 1.55% | 8.30% ± 1.1% |
| A1c (mean) end of study Standard Group | 8.5% (median) | 7.30% ± 1.26% | 7.73% ± 1.09% |
| A1c (mean ± SD) end of study Intensive Group | 7.9% (median) | 6.53% ± 0.91% | 6.57% ± 1.01% |
| Coronary heart disease at baseline | Study excluded those with angina, congestive heart failure, myocardial infarction in last year, or two or more coronary heart dis ease events | 35% | 32% |
| Aspirin base and f/u | – | 44% → 56% | 54% → 76% |
| Blood pressure base and f/u intensive | 135/82 → 138/77 | 145/81 → 135/73 | 136/75 → 128/67 |
| Blood pressure base and f/u standard | 135/82 → 139/77 | 145/80 → 138/74 | 136/75 → 129/68 |
| % On statin at baseline and f/u | <1% →− | 28% → 46% | 62% → 88% |
| % Current smokers at baseline | 31% | 14% | 14% |
| Renal eligibility criteria | Serum creatinine < 175 μmol/l | Serum creatinine < 2 mg/dl | Serum creatinine <1.5 mg/dl |
—
, not available.