Table 1. Beneficial effects of HDAC inhibition or suppression in polyQ disease models.

HDACi/ treatment	PolyQ model	Effect	Refs.
SAHA	HD R6/2 mice	Improvement of motor skills Reduction of HTT aggregates Restoration of BDNF levels	57 , 58
SAHA	Human HTT in yeast	Inhibition of neurotoxic metabolites	59
NaBu	SCA3 mice	Restoration of histone acetylation level Improvement of neurological symptoms	60
NaBu	HD R6/2 mice	Improvement of neurological symptoms	22
4b	HD R6/2 mice	Improvement of motor, body-weight and brain symptoms	61
4b-related compounds	HD R6/2 mice	Neuroprotection	62
Sir2 / Rpd3 reduction	HD flies	Neuroprotection	63
Sirt1 increase	HD mice	Improvement of motor skills and decreased neurodegeneration	64