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. Author manuscript; available in PMC: 2013 Apr 15.
Published in final edited form as: Clin Cancer Res. 2012 Aug 28;18(20):5650–5661. doi: 10.1158/1078-0432.CCR-12-1322

Figure 4.

Figure 4

The antitumor and pharmacodynamic effects of CCT244747 combined with irinotecan or gemcitabine in human tumor xenografts. A, Antitumor activity of gemcitabine 100mg/kg i.v. and CCT244747 75mg/kg p.o. alone or in combination in HT29 colon tumor xenografts. B, Biomarker changes occurring 48h (day 18) after the last dose of CCT244747 following drug treatment as shown in A. Protein expression was measured using western blotting as described in Materials and Methods and the legend to Figure 2. C, Efficacy of irinotecan (25mg/kg i.p.) or CCT244747 (150mg/kg p.o.) alone and in combination in SW620 human colon tumor xenografts. D, Efficacy of gemcitabine (100mg/kg i.v.) or CCT244747 (75mg/kg p.o.) alone or combined in Calu6 human lung cancer xenografts. Values are mean±SE for 4-6 animals per point. Tumor size and body weight were assessed as described in Materials and Methods.