Table 1.
LHV4 genes for which predictions were made regarding functional properties and comparison with other simplexviruses
| LHV-4a | CeHV-2a | HHV-2a | BHV-2a# | ||
|---|---|---|---|---|---|
| Gene | Predicted Functions** | aa | %*/aa | %*/aa | %*/aa |
| RL2 | immediate early protein | 569 | 42.7/688 | 43.2/702 | |
| orf7 | Hypothetical protein | 132 | |||
| orf8 | Hypothetical protein | 70 | |||
| UL1 | glycoprotein L | 156 | 53.6/232 | 54/204 | |
| UL2 | uracil-DNA glycosylase | 245 | 57.4/316 | 64/255 | |
| UL3 | nuclear phosphoprotein | 202 | 55.6/227 | 62/233 | 70/213 |
| UL4 | nuclear protein | 206 | 48.2/204 | 46/201 | 62/210 |
| UL5 | helicase-primase helicase subunit | 885 | 78.3/875 | 74/881 | |
| UL6 | capsid portal protein | 651 | 57.9/678 | 61/678 | |
| UL7 | tegument protein | 283 | 46.4/296 | 48/296 | |
| UL8 | helicase-primase subunit | 733 | 37.6/758 | 39/752 | 52/733 |
| UL9 | DNA replication-origin replication helicase | 831 | 64.5/879 | 69/867 | |
| UL10 | glycoprotein M | 410 | 45.2/450 | 51/467 | |
| UL11 | myristylated tegument protein | 86 | 45.9/87 | 42/96 | |
| UL12 | alkaline exonuclease | 577 | 53/615 | 49/620 | |
| UL13 | tegument serine/threonine protein kinase | 504 | 51.7/514 | 54/518 | |
| UL14 | tegument protein | 285 | 52.6/214 | 60/219 | |
| UL15 exon1 | DNA packaging terminase subunit 1 | 466 | 65.5/343 | 66/343 | |
| UL15 exon2 | DNA packaging terminase subunit 1 | 609 | 75.4/392 | 79/391 | |
| UL16 | tegument protein | 347 | 47.7/362 | 49/449 | |
| UL17 | DNA packaging tegument protein | 672 | 55/703 | 56/702 | |
| UL18 | capsid protein | 314 | 72.4/317 | 70/318 | 80/316 |
| UL19 | major capsid protein | 1025 | 70.9/1377 | 74/1374 | 84/1385 |
| UL20 | envelope protein | 223 | 50.7/225 | 48/222 | 64.4/223 |
| UL21 | tegument protein | 521 | 41.8/526 | 44/532 | 56/522 |
| UL22 | glycoprotein H | 845 | 40.5/863 | 42/838 | 57/867 |
| UL23 | thymidine kinase | 310 | 42.4/378 | 47/376 | 56/323 |
| UL24 | nuclear protein | 258 | 51.8/260 | 50/281 | 64/265 |
| UL25 | DNA packaging tegument protein | 580 | 59.3/577 | 65/585 | 72/579 |
| UL26 | capsid maturation protease | 539 | 61.1/594 | 52/636 | 50/562 |
| UL26.5 | capsid morphogenesis; capsid scaffold protein | 336 | 43.7/292 | 38.6/329 | 49/292 |
| UL27 | glycoprotein B | 878 | 68/885 | 66.7/901 | 79/917 |
| UL28 | DNA packaging terminase subunit 2 | 771 | 60.6/784 | 64/785 | 71/664 |
| UL29 | ICP8 single-stranded binding protein | 1295 | 65.7/1196 | 74/1196 | 80/1186 |
| orf54 | Hypothetical protein | 119 | |||
| UL30 | DNA polymerase | 1178 | 68/1226 | 65/1240 | 73/1211 |
| UL31 | nuclear egress laminar protein | 375 | 66.9/304 | 70/305 | |
| UL32 | DNA packaging protein | 612 | 57.6/590 | 62/598 | |
| UL33 | DNA packaging protein | 159 | 54.7/135 | 59/130 | |
| UL34 | nuclear egress protein | 258 | 64.9/266 | 69/276 | |
| UL35 | small capsid protein | 105 | 54/114 | 56/112 | |
| UL36 | large tegument protein | 2803 | 51/3070 | 50/3122 | |
| UL37 | tegument protein | 1071 | 54.5/1271 | 59/1114 | |
| UL38 | triplex capsid protein VP19C | 501 | 48.8/459 | 59/466 | |
| orf73 | Hypothetical protein | 49 | |||
| UL39 | ribonucleotidereductase subunit 1 | 890 | 63.8/975 | 61/1142 | 75/784 |
| UL40 | Ribonucleotide reductase subunit 2 | 314 | 74.4/325 | 75/337 | 83/313 |
| UL41 | tegument host shut off protein | 484 | 51.9/484 | 54/492 | 66/487 |
| orf79 | Hypothetical protein | 94 | |||
| UL42 | DNA polymerase processivity factor | 454 | 44.9/438 | 59/470 | 52/449 |
| UL43 | envelope protein | 401 | 26.1/381 | 30/414 | 51/391 |
| orf83 | Hypothetical protein | 42 | |||
| UL44 | glycoprotein C | 429 | 43.3/464 | 40/480 | 56/425 |
| UL45 | Envelope protein UL45 | 158 | 42.3/174 | 43/172 | 55/166 |
| UL46 | tegument protein VP11/12 | 632 | 45.3/680 | 49/721 | |
| UL47 | tegument protein VP13/14 | 676 | 46.9/674 | 51/696 | |
| UL48 | transactivating tegument protein VP16 | 523 | 52.6/488 | 53/490 | |
| orf92 | Hypothetical protein | 99 | |||
| UL49 | Tegument protein VP22 | 206 | 38.2/275 | 42.1/300 | |
| UL49A | Glycoprotein N | 97 | 50/78 | 33.3/87 | |
| UL50 | deoxyuridine triphosphatase | 360 | 39.2/367 | 40/369 | |
| UL51 | tegument protein | 239 | 66/228 | 58/244 | |
| UL52 | helicase primase subunit | 1038 | 57/1053 | 56/1066 | |
| UL53 | glycoprotein K | 334 | 53/335 | 56/338 | |
| UL54 | ICP27 | 502 | 30/510 | 47/512 | |
| UL55 | nuclear protein | 181 | 40.9/191 | 47/186 | 65/193 |
| UL56 | membrane protein | 150 | 27.8/226 | 38.5/235 | |
| orf109 | Hypothetical protein | 150 | |||
| RL2 | ICP0 | 569 | 42.7/688 | 43.2/702 | |
| orf116 | Hypothetical protein | 600 | |||
| RS1 | transcription activator, ICP4 | 771 | 51.9/1185 | 45.1/1277 | |
| orf120 | Hypothetical protein | 682 | |||
| orf123 | Hypothetical protein | 144 | |||
| orf125 | Hypothetical protein | 86 | |||
| US1 | ICP22 | 384 | 40/431 | 43/413 | |
| US2 | virion protein | 325 | 48/276 | 43/291 | |
| US3 | protein kinase | 784 | 57/454 | 61/481 | |
| US4 | glycoprotein G | 808 | 36/606 | 33/699 | |
| orf130 | Hypothetical protein | ||||
| US6 | glycoprotein D | 403 | 60/395 | 63/393 | |
| US7 | Virion glycoprotein I | 335 | 32.7/399 | 35/372 | |
| US8 | glycoprotein E | 504 | 35/540 | 38/545 | |
| US8.5 | membrane protein | 96 | 48.9/102 | 54.5/146 | |
| US9 | type 2 membrane protein; tegument-associated; localizes envelope proteins | 88 | 32.4/91 | 39/89 | |
| US10 | virion protein | 153 | 41/276 | 34/302 | |
| US11 | translational regulation | 349 | 42.3/115 | 38/151 | |
| US12 | inhibits antigen presentation #TAP transporter inhibitor ICP47 | 133 | 59.2/78 | 42.1/86 | |
| orf140 | Hypothetical protein | 86 | |||
| orf142 | Hypothetical protein | 47 | |||
| orf143 | Hypothetical protein | 369 | |||
| RS1 | transcription activator, ICP4 | 771 | 51.9/1185 | 45.1/1277 |