Table 2. MCI participant demographic and baseline data.
| MCI group | N | %/#Female | Age[years] | MMSE | ADAS-Cog | CDR-SB | Aβ[pg/ml] | Ptau[pg/ml] |
| All | 311‡ | 37/117 | 74.8 (7.4) | 27.0 (1.8) | 11.6 (4.3) | 1.6 (0.9) | 162.2 (52.9)* | 35.8 (17.2)$ |
| Aβ− | 39* | 31/12 | 75.3 (9.1) | 27.2 (1.9) | 10.7 (4.7) | 1.3 (0.7) | 245.9 (26.0) | 20.7 (8.5) |
| Aβ+ | 127* | 36/46 | 74.3 (6.8) | 26.8 (1.8) | 12.2 (4.5) | 1.6 (0.9) | 136.5 (25.0) | 40.4 (16.6) |
| Ptau− | 47$ | 26/12 | 75.7 (7.7) | 27.2 (1.8) | 10.0 (4.4) | 1.5 (0.9) | 211.3 (56.2) | 17.4 (3.4) |
| Ptau+ | 120$ | 38/46 | 74.2 (7.3) | 26.8 (1.8) | 12.6 (4.5) | 1.6 (0.9) | 142.8 (36.3)$ | 43.0 (15.0) |
| MRI− | 153‡ | 34/52 | 74.8 (7.5) | 27.3 (1.7) | 9.9 (3.7) | 1.4 (0.7) | 176.1 (60.0)∧ | 30.8 (16.3)∧ |
| MRI+ | 156‡ | 41/64 | 74.8 (7.3) | 26.7 (1.7) | 13.2 (4.3) | 1.7 (1.0) | 151.2 (44.0)∧ | 40.1 (17.0)∧ |
| Aβ−Ptau− | 31 | 26/8 | 75.1 (8.6) | 27.3 (1.8) | 9.7 (4.1) | 1.3 (0.7) | 245.9 (27.5) | 17.3 (3.7) |
| Aβ+Ptau− | 16 | 25/4 | 75.2 (5.5) | 27.1 (1.7) | 10.5 (5.2) | 1.8 (1.1) | 144.3 (30.1) | 17.8 (2.7) |
| Aβ+Ptau+ | 111 | 38/42 | 74.2 (7.0) | 26.8 (1.8) | 12.4 (4.4) | 1.6 (0.9) | 135.4 (24.1) | 43.6 (15.2) |
| Aβ+MRI− | 48 | 31/15 | 75.2 (7.0) | 27.1 (1.8) | 10.0 (3.8) | 1.4 (0.6) | 136.5 (27.0) | 37.1 (17.0) |
| Aβ+MRI+ | 77 | 39/30 | 73.8 (6.7) | 26.6 (1.7) | 13.5 (4.4) | 1.8 (1.1) | 136.7 (24.2) | 42.6 (16.3) |
| Aβ−Ptau−MRI− | 22 | 32/7 | 73.5 (9.4) | 27.5 (1.8) | 8.6 (3.7) | 1.3 (0.6) | 245.4 (29.4) | 17.6 (3.7) |
| Aβ+Ptau−MRI− | 9 | 11/1 | 75.7 (5.0) | 27.3 (1.4) | 8.9 (3.3) | 1.2 (0.7) | 152.6 (27.1) | 17.8 (2.3) |
| Aβ−Ptau+MRI− | 5 | 40/2 | 76.8 (10.0) | 27.6 (1.5) | 12.2 (0.7) | 1.1 (0.7) | 251.8 (20.2) | 28.2 (3.3) |
| Aβ+Ptau+MRI− | 39 | 36/14 | 75.0 (7.4) | 27.1 (2.0) | 10.2 (3.9) | 1.4 (0.5) | 132.7 (25.9) | 41.6 (15.6) |
| Aβ+Ptau+MRI+ | 71 | 38/27 | 73.8 (6.7) | 26.7 (1.7) | 13.7 (4.2) | 1.7 (1.1) | 136.9 (23.3) | 44.7 (15.0) |
‡
Two MCI participants were not classified for MRI+/− due to technical issues; both had cognitive data and were Aβ+; 1 was ptau−, the other ptau+.
*
166 (53.4%) of the 311 MCI subjects had CSF Aβ data. All have ptau; includes the two in ‡.
$
167 (53.7%) of the 311 MCI subjects had CSF ptau data. One of these does not have Aβ data, but has cognitive data and is ptau+MRI+. The 167 include the two in ‡.
∧Only 75 MRI− had CSF Aβ and ptau data; only 89 MRI+ had CSF Aβ data; 90 MRI+ had ptau data.