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. 2012 Oct 17;7(10):e46560. doi: 10.1371/journal.pone.0046560

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© 2012 Han et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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Real-time polymerase chain reaction analysis was performed with bone marrow cells from 6 to 8-week-old control mice (0 Gy, black bar) and sub-TBI (5 and 10 Gy) mice (gray bars). (A) The mRNA relative expression of Ig heavy-chain (IgH) loci V_H7183-DJ_H and (B) V_HJ558-DJ_H; (C) the pre-BCR genes surrogate light chain (SLC) component λ5; (D) IgL κ gene (Vκ1-JCκ); and (E) IgL λ gene (Vλ1-JCλ1) rearrangements. Results are representative of 3 independent experiments. * represents P<0.05 and ** represents P<0.01, as compared with the 0-Gy group (n = 5).