Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2012 Oct 17;7(10):e46417. doi: 10.1371/journal.pone.0046417

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2012 Helikar et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

PMC Copyright notice

As discussed in the main text, the regulation of Rac by Pix/Cool is associated with three different scenarios described by three conditions (and subconditions which are not displayed). When multiple conditioned species are added as part of a condition (as is the case with the first condition of the Pix/Cool module, where the activation states of both PAK and G determine the effects of Pix/Cool on Rac), the user first drags the species of interest into the condition box. Subsequently the user is prompted to select the relationship between the species (boxed in red). The available relationships include “Independent” and “Co-operative”, corresponding to the OR and AND Boolean operators, respectively. The Co-operative relationship is selected for the first condition of the Pix/Cool module. Note that any number of conditioned species can be added as part of a condition, and the selected relationship applies to all conditioned species. Similarly when multiple conditions are specified for a regulation module (as is the case with the Pix/Cool module), the user needs to also specify either an Independent or Co-operative relationship for the conditions (highlighted in blue). In the case of Pix/Cool, there are three independent conditions.

Inline graphic — As discussed in the main text, the regulation of Rac by Pix/Cool is associated with three different scenarios described by three conditions (and subconditions which are not displayed). When multiple conditioned species are added as part of a condition (as is the case with the first condition of the Pix/Cool module, where the activation states of both PAK and G determine the effects of Pix/Cool on Rac), the user first drags the species of interest into the condition box. Subsequently the user is prompted to select the relationship between the species (boxed in red). The available relationships include “Independent” and “Co-operative”, corresponding to the OR and AND Boolean operators, respectively. The Co-operative relationship is selected for the first condition of the Pix/Cool module. Note that any number of conditioned species can be added as part of a condition, and the selected relationship applies to all conditioned species. Similarly when multiple conditions are specified for a regulation module (as is the case with the Pix/Cool module), the user needs to also specify either an Independent or Co-operative relationship for the conditions (highlighted in blue). In the case of Pix/Cool, there are three independent conditions.