Table 3. Predictors of limitations in sports and daily activities (physical function score <45) from two multivariable regression models in survivors.

	Limited in sports						Limited in daily activities
	%a		OR	95% CI		pc	%b	OR	95% CI		pc
Gender						0.367					0.158
Male	8.5		1				13.2	1
Female	10.5		1.23	0.78	1.95		16.7	1.31	0.90	1.90
Current age (years)						0.061					0.496
≤20	10.3		1.13	0.62	2.07		19.0	1.45	0.90	2.32
20–29.9	9.7		1				13.5	1
30–39.9	6.5		0.63	0.32	1.22		14.6	1.05	0.64	1.72
≥40	20.5		2.70	1.02	7.16		15.4	0.97	0.36	2.63
Parents education						0.035					0.008
Primary education	4.6		0.40	0.13	1.18		20.5	1.89	1.03	3.49
Secondary education	9.8		1				13.7	1
Tertiary education	8.9		0.98	0.51	1.87		12.6	1.01	0.58	1.76
Unknown	15.9		2.97	1.19	7.39		26.6	2.80	1.46	5.38
Age at diagnosis (years)						0.964					0.387
<5	8.1		1				14.6	1
5–9.9	9.7		1.04	0.55	1.97		14.3	0.72	0.43	1.19
≥10	10.7		1.10	0.56	2.14		15.6	0.92	0.54	1.56
Diagnosis (ICCC3 main groups)						<0.001					<0.001
I Leukemia	4.0		1				9.2	1
II Lymphoma	5.7		1.16	0.49	2.74		8.2	0.89	0.45	1.75
III CNS tumor	23.2		9.40	4.26	20.74		30.5	5.76	3.08	10.80
IV Neuroblastoma	11.1		3.77	1.23	11.55		15.6	2.42	0.95	6.17
V Retinoblastoma	19.1		8.55	2.26	32.33		19.1	2.88	0.82	10.10
VI & VII Renal & hepatic tumord	6.8		1.65	0.57	4.80		16.0	2.19	1.04	4.63
VIII Bone tumor	34.2		13.59	5.55	33.28		45.2	10.87	5.04	23.45
IX Soft tissue sarcoma	12.7		2.87	1.07	7.70		16.1	1.76	0.77	4.04
X Germ cell tumor	6.9		2.11	0.44	10.12		10.0	1.15	0.31	4.19
XI & XII Other tumore	18.2		5.72	1.03	31.76		16.7	1.86	0.34	10.02
Langerhans Cell Histiocytosis	4.4		1.62	0.35	7.52		15.2	2.91	1.15	7.35
Treatment						<0.001					<0.001
Surgery only	8.2	0.35		0.13	0.90		13.2	0.50	0.23	1.07
Chemotherapyf	7.0	1					10.3	1
Radiotherapyg	13.6	1.61		0.90	2.88		20.6	2.08	1.31	3.32
Bone marrow transplantation	8.1	0.85		0.22	3.28		25.6	2.98	1.24	7.14
Relapse						0.880					0.326
No	9.3	1					14.2	1
Yes	11.3	1.06		0.52	2.13		20.6	1.32	0.76	2.29

Abbreviations: CI, Confidence Interval; CNS, Central Nervous System; ICCC-3, International Classification of Childhood Cancer Third Edition; OR, Odds Ratio.

^aProportion reporting a limitation in sports in each stratum. Column percentages are given.

^bProportion reporting a limitation in daily activities in each stratum. Column percentages are given.

^cGlobal p-values calculated with a likelihood ratio test.

^dHepatic and renal tumors have been merged for this analysis.

^eOther malignant epithelial neoplasm, malignant melanoma and other or unspecified malignant neoplasm.

^fChemotherapy may include surgery.

^gRadiotherapy may include surgery and/or chemotherapy.