Table 2. Samples with a reduced PK activity (between 39 and 75% of the normal control) and respective infection status and malaria outcome and 829 locus genotype.
PK Activity U/g Hb | |||||||||
# | Sample | Assay | Activity | Average | Control N | Average/Control N | Control DEF | Inf/Malaria outcome | 829G/A |
1 | BS_128 | 1 | 1.69 | 1.69 | 3.48 | 0.49 | 0.85 | NI | GG |
2 | BS_176 | 1 | 1.88 | ||||||
BS_176 | 2 | 1.93 | 1.91 | 3.48 | 0.55 | 0.85 | NI | GG | |
3 | BS_197 | 1 | 1.56 | ||||||
BS_197 | 2 | 1.34 | 1.45 | 3.48 | 0.42 | 0.85 | NI | GA | |
4 | BS_199 | 1 | 1.73 | ||||||
BS_199 | 2 | 0.99 | 1.36 | 3.48 | 0.39 | 0.85 | NI | GA | |
5 | BS_212 | 1 | 1.85 | ||||||
BS_212 | 2 | 1.43 | 1.64 | 3.48 | 0.47 | 0.85 | NI | GA | |
6 | BS_220 | 1 | 1.35 | ||||||
BS_220 | 2 | 1.52 | 1.44 | 3.48 | 0.41 | 0.85 | NI | GG | |
7 | BS_230 | 1 | 1.46 | ||||||
BS_230 | 2 | 1.59 | 1.53 | 3.48 | 0.44 | 0.85 | NI | AA | |
8 | BS_327 | 1 | 1.74 | ||||||
BS_327 | 2 | 1.96 | 1.85 | 3.48 | 0.53 | 0.85 | NI | GG | |
9 | N_1159 | 1 | 1.93 | ||||||
N_1159 | 2 | 2.27 | 2.10 | 2.91 | 0.72 | 0.73 | NI | GG | |
10 | N_1391 | 1 | 2.19 | 2.19 | 2.91 | 0.75 | 0.73 | NI | GG |
11 | N_1464 | 1 | 1.69 | 1.69 | 2.91 | 0.58 | 0.73 | NI | GG |
12 | O_2341 | 1 | 1.35 | 1.35 | 2.91 | 0.46 | 0.73 | SM | GA |
BS: samples collected in the Blood Bank; O and N: samples collected in the Department of Pediatrics; Inf/Malaria outcome: infection status and malaria outcome; 829G/A: 829 genotype; NI: non-infected; SM: severe malaria.