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. 2012 Oct 17;7(10):e47287. doi: 10.1371/journal.pone.0047287

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© 2012 Gros et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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A Effect of trastuzumab and ADM3100 treatment on proliferation (%) of OE19 cells compared to control in the lactate-dehydrogenase assay. Receptor inhibition leads to reduced proliferation of cells. It shows a significant reduction of cell proliferation under HER2- and CXCR4-receptor inhibition after treatment with trastuzumab (p = 0.005) as well as with AMD3100 (p = 0.02) compared to the untreated control. B Microscopic evaluation shows dose-dependent effect of SDF-1α-stimulated cell migration on OE19 cells. C A relevant effect of SDF-1α on cell migration is observed at 250 ng/ml compared to unstimulated cells (control).