Table 2.

Resolvin, protectin, and maresin induced bioactions.

Cell type	Bioactions in vitro
Resolvin E1
Macrophages	Stimulates efferocytosis while reducing IFN-γ and IL-6 (Schwab et al., 2007)
PMN	Decreases transendothelial and epithelial migration (Campbell et al., 2007)
	Stimulates L-selectin shedding, while reducing CD18 expression and inhibiting PMN rolling in vivo (Dona et al., 2008)
	Attenuates BLT1 depended TNF-α and NF-κB activation (Arita et al., 2007)
	Enhances CCR5 expression on apoptotic PMN (Ariel et al., 2006)
Dendritic cells	Inhibits migration (Arita et al., 2005a)
	Reduces IL-12 production from DCs stimulated with pathogen extract (Arita et al., 2005a)
Platelets	Disruptes platelet aggregation (Dona et al., 2008; Fredman et al., 2010)
Resolvin D1
Microglia cells	Inhibits IL-1β expression (Serhan et al., 2002)
Protectin D1
PMN	Enhances CCR5 expression on apoptotic PMN (Ariel et al., 2006)
Mφ	Stimulates efferocytosis while reducing IFN-γ (Schwab et al., 2007)
T cell	Promotes apoptosis, inhibits TNF-α and IFN-γ (Ariel et al., 2005)
Glia cells	Reduces IL-1β-induced NF-κB activation and COX2 expression (Marcheselli et al., 2003), reduces amyloid β-42-induced nerotoxicity, promotes amyloid β-induced apoptosis (Lukiw et al., 2005)
Epithelium	Protects from apoptosis induced by oxidative stress (Mukherjee et al., 2004)
Maresin 1
Macrophage	Stimulates efferocytosis (Serhan et al., 2009)