Fig. 3.

VPA, administered prior to extinction training, rescues impaired extinction acquisition and deficient extinction consolidation/expression in S1 mice. A) Schematic of experimental design. B) During extinction training (Ext.), freezing was lower in VPA treated S1 mice than VEH S1 mice on CS presentation blocks 2–8. Lower freezing was observed in VPA treated S1 mice during extinction retrieval (Ext. Ret.). No differences in freezing was observed between VEH and VPA groups during “normal” fear conditioning (Cond.). 0 = baseline/pre-tone freezing levels. *p < 0.05 VEH vs. VPA.