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MS-275, administered prior to extinction training (arrow), does not rescue deficient extinction acquisition or deficit extinction consolidation/retrieval in S1 mice. A) Schematic of experimental design. B) Freezing responses did not differ between VEH or 5 or 10 mg/kg MS-275 groups during “normal” fear conditioning (Cond.), extinction training (Ext.) or an extinction retrieval session (Ext. Ret.). 0 = baseline/pre-tone freezing levels.
