Table 2. Predictors of White matter Disease.

Various clinical and pathological risk factors for white matter disease were assessed in our cohort using univariate ordinal regression. The odds ratio refers to the increase in odds of the outcome due to a single step increase in the input variable. CAD = coronary artery disease. Composite AD pathology refers to a weighted sum of the Braak and CERAD scores. JNC-7 refers to the four categories of blood pressure detailed in the Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure. The “n” value for each risk factor refers to the number of individuals with that condition out of the 50 individuals in the cohort, while the other numbers in parentheses refer to the grades of the indicated risk factor.

	CHS White Matter Score as Outcome
	Univariate Ordinal Regression
Input Variable	O.R. (95% CI)	P -Value
Age (75-101)	1.0 (0.9-1.1)	0.53
Female Sex (n=19)	1.7 (0.6-5.8)	0.30
Diabetes (n=13)	0.9 (0.3-2.6)	0.80
Any Hypertension (n=34)	2.5 (0.9-7.4)	0.09
JNC-7 Hypertension Grade (1-4)	2.0 (1.3-3.4)	0.03
CAD (n=19)	1.4 (0.5-4.3)	0.40
Intracranial Atherosclerosis (1-3)	1.9 (1.0-3.6)	0.04
Framingham Risk Score (1-3)	1.1 (0.6-2.1)	0.71
Brain Infarct (n=23)	1.9 (0.7-5.2)	0.21
CERAD Score (0-3)	2.9 (1.5-5.8)	0.001
Braak Score (1-6)	2.1 (1.3-3.8)	0.003
Composite AD Score (2-6)	3.2 (1.7-5.9)	0.0001
Composite AD Score ≥4 (n=29)	4.7 (1.46-14)	0.003
Amyloid Angiopathy (n=23)	2.1 (0.8-6.0)	0.12
Dementia Diagnosis (n=26)	3.1 (1.2-8.9)	0.02