Table 3. Multivariate Regression.
Two multivariate ordinal regression models were constructed, using CHS white matter score as the outcome, and the three indicated clinical or pathologic conditions plus age at death and sex as the independent variables for each model. The odds ratio refers to the increase in odds of the outcome due to a single step increase in the input variable. Composite AD pathology refers to a weighted sum of the Braak and CERAD scores. JNC-7 grade refers to the 4 categories of blood pressure detailed in the Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure, while the intracranial atherosclerosis score was graded 1-3 as described in the Methods section.
| O.R. (95% CI) | P-Value | |
|---|---|---|
| Model 1 | ||
| Composite AD Pathology Score | 2.8 (1.5-5.3) | 0.001 |
| JNC-7 Hypertension Grade | 2.0 (1.1-3.7) | 0.03 |
| Intracranial Atherosclerosis Score | 1.1 (0.5-2.3) | 0.70 |
| Model 2 | ||
| Composite AD Pathology Score | 2.8 (1.5-5.1) | 0.001 |
| JNC-7 Hypertension Grade | 2.1 (1.2-3.8) | 0.01 |
| Presence of any Brain Infarct | 1.5 (0.5-4.3) | 0.41 |