Table 2. Repeated Measures MANOVA in Three Intervention Group (Metformin, Pioglitazone, Silymarin) After two Months Follows Up.
| Pioglitazone, Mean ± SD | Metformin, Mean ± SD | Silymarin, Mean ± SD | F (Time Treatment) | P value | ||||
| Before | After | Before | After | Before | After | |||
| Weight, kg | 76.95 ± 9.17 | 77.82 ± 9.32 | 76.9 ± 9.52 | 75.46 ± 9.9 | 77.00 ± 9.50 | 77.09 ± 9.52 | 46.127 | 0.001 |
| BMI a, kg/m 2 | 27.36 ± 1.65 | 27.67 ± 1.77 | 27.53 ± 1.85 | 27.00 ± 1.98 | 27.44 ± 1.65 | 27.48 ± 1.70 | 43.93 | 0.001 |
| FBS a, mmol/L | 95.45 ± 6.88 | 84.91 ± 5.26 | 95.09 ± 7.00 | 87.41 ± 5.28 | 95.95 ± 6.11 | 93.95 ± 5.74 | 56.240 | 0.001 |
| TG a, mg/dL | 252.18 ± 52.81 | 224.09 ± 47.06 | 248.36 ± 53.20 | 222.73 ± 50.39 | 254.18 ± 56.04 | 239.09 ± 52.72 | 9.546 | 0.001 |
| CHOL a, mg/dL | 195.68 ± 34.35 | 178.64 ± 31.95 | 193.00 ± 35.69 | 175.86 ± 31.95 | 191.68 ± 33/81 | 181.32 ± 32.44 | 3.818 | 0.027 |
| AST a, IU/L | 55.0 ± 9.49 | 37.59 ± 8.67 | 54.86 ± 11.29 | 42.5 ± 10.02 | 56 ± 11.07 | 37.77 ± 8.78 | 6.264 | 0.003 |
| ALT a, IU/L | 77.45 ± 18.53 | 52.27 ± 14.53 | 78.36 ± 19.88 | 60.95 ± 14.21 | 78.73 ± 19.71 | 53.05 ± 13.99 | 5.749 | 0.005 |
| Insulin Levels, mmol/L | 14.20 ± 3.78 | 11.76 ± 3.26 | 14.17 ± 3.99 | 12.06 ± 3.57 | 14.20 ± 3.82 | 13.50 ± 3.70 | 28.12 | 0.001 |
| HOMA-IR a | 2.89 ± 0.93 | 2.12 ± 0.67 | 2.87 ± 0.98 | 2.24 ± 0.77 | 2.9 ± 0.93 | 2.7 ± 0.85 | 27.56 | 0.001 |
aAbbreviations: ALT, alanine aminotransferase; AST, aspartate aminotransferase; BMI, body mass index; CHOL, cholesterol; FBS, fasting blood sugar; HOMA-IR, homeostasis model assessment index for insulin resistance; TG, triglyceride