Table 2.
The genotype and allelic frequencies and carriage rates of six investigated single nucleotide polymorphisms (SNPs) of cytokine genes in 1) patients that developed prosthetic joint infection after total joint arthroplasty (TJA with PJI, N = 89), 2) patients without prosthetic infection (TJA without PJI, N = 214) and 3) the group of healthy control subjects (N = 168)
| |
TJA with PJI |
TJA without PJI |
Healthy Controls (HC) |
|||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Genotype frequencies | Allelic frequencies | Carriage rates | Genotype frequencies | Allelic frequencies | Carriage rates | Genotype frequencies | Allelic frequencies | Carriage rates | ||||||||||
| IL1B-511* |
CC |
0.31 |
C |
0.61 |
C |
0.91 |
CC |
0.49 |
C |
0.69 |
C |
0.90 |
CC |
0.45 |
C |
0.68 |
C |
0.91 |
| |
CT |
0.60 |
|
|
|
|
CT |
0.42 |
|
|
|
|
CT |
0.46 |
|
|
|
|
| |
TT |
0.09 |
T |
0.39 |
T |
0.69 |
TT |
0.10 |
T |
0.31 |
T |
0.51 |
TT |
0.09 |
T |
0.32 |
T |
0.55 |
| IL1B + 3962 |
CC |
0.59 |
C |
0.76 |
C |
0.94 |
CC |
0.57 |
C |
0.75 |
C |
0.92 |
CC |
0.61 |
C |
0.78 |
C |
0.96 |
| |
CT |
0.35 |
|
|
|
|
CT |
0.35 |
|
|
|
|
CT |
0.35 |
|
|
|
|
| |
TT |
0.06 |
T |
0.24 |
T |
0.41 |
TT |
0.08 |
T |
0.25 |
T |
0.43 |
TT |
0.04 |
T |
0.22 |
T |
0.39 |
| TNF-308 |
GG |
0.74 |
G |
0.85 |
G |
0.96 |
GG |
0.72 |
G |
0.85 |
G |
0.97 |
GG |
0.68 |
G |
0.83 |
G |
0.98 |
| |
GA |
0.21 |
|
|
|
|
GA |
0.25 |
|
|
|
|
GA |
0.30 |
|
|
|
|
| |
AA |
0.04 |
A |
0.15 |
A |
0.26 |
AA |
0.03 |
A |
0.15 |
A |
0.28 |
AA |
0.02 |
A |
0.17 |
A |
0.32 |
| TNF-238 |
GG |
0.91 |
G |
0.96 |
G |
1.00 |
GG |
0.93 |
G |
0.96 |
G |
1.00 |
GG |
0.92 |
G |
0.96 |
G |
1.00 |
| |
GA |
0.09 |
|
|
|
|
GA |
0.07 |
|
|
|
|
GA |
0.08 |
|
|
|
|
| |
AA |
0.00 |
A |
0.04 |
A |
0.09 |
AA |
0.00 |
A |
0.04 |
A |
0.07 |
AA |
0.00 |
A |
0.04 |
A |
0.08 |
| IL6–174 |
GG |
0.33 |
G |
0.56 |
G |
0.79 |
GG |
0.36 |
G |
0.58 |
G |
0.79 |
GG |
0.33 |
G |
0.58 |
G |
0.84 |
| |
GC |
0.46 |
|
|
|
|
GC |
0.43 |
|
|
|
|
GC |
0.51 |
|
|
|
|
| |
CC |
0.21 |
C |
0.44 |
C |
0.67 |
CC |
0.21 |
C |
0.42 |
C |
0.64 |
CC |
0.16 |
C |
0.42 |
C |
0.67 |
| IL6 nt565 |
GG |
0.34 |
G |
0.57 |
G |
0.80 |
GG |
0.38 |
G |
0.59 |
G |
0.81 |
GG |
0.33 |
G |
0.59 |
G |
0.85 |
| |
GA |
0.46 |
|
|
|
|
GA |
0.43 |
|
|
|
|
GA |
0.52 |
|
|
|
|
| AA | 0.20 | A | 0.43 | A | 0.66 | AA | 0.19 | A | 0.41 | A | 0.62 | AA | 0.15 | A | 0.41 | A | 0.67 | |
The data are presented as relative values.
* IL1B-511*T carriage rate (Pearson’s Chi-square test, 1 degree of freedom, d.f.):
TJA with PJI versus TJA without PJI: p = 0.006, pcorr = 0.037; odds ratio = 2.06, 95%CI: 1.22-3.47.
TJA with PJI versus HC: p = 0.04, pcorr > 0.05; odds ratio = 1.76, 95%CI: 1.02-3.02.
* Distribution of IL1B-511 genotypes (Pearson’s Chi-square test, 2 d.f.):
TJA with PJI versus TJA without PJI: p = 0.014, pcorr > 0.05.
* Allelic frequency of IL1B-511*T (Pearson’s Chi-square test, 1 d.f.):
TJA with PJI versus TJA without PJI: p = 0.052.