Table 3.
Estimated frequencies of IL1B, TNF and IL6 two-locus (SNP) haplotypes in patients with prosthetic joint infection after total joint arthroplasty (TJA with PJI), those without infection (TJA without PJI) and Czech healthy controls. Data are given as proportions (relative numbers) of each possible haplotype
| TJA with PJI | TJA without PJI | Healthy Controls | |
|---|---|---|---|
|
IL1Bhaplotypes |
|
|
|
|
−511 / +3962 |
|
|
|
| CC |
0.398 |
0.476 |
0.479 |
| CT |
0.214 |
0.217 |
0.195 |
| TC |
0.367 |
0.272 |
0.304 |
| TT |
0.022 |
0.035 |
0.022 |
| Overall LD p value |
0.003 |
0.001 |
0.002 |
|
TNFhaplotypes |
|
|
|
|
−308 / -238 |
|
|
|
| AG |
0.107 |
0.152 |
0.170 |
| GA |
0.045 |
0.040 |
0.042 |
| GG |
0.848 |
0.808 |
0.789 |
| AA |
0.000 |
0.000 |
0.000 |
| Overall LD p value |
0.607 |
0.289 |
0.017 |
|
IL6haplotypes |
|
|
|
|
−174 / nt565 |
|
|
|
| CA |
0.433 |
0.407 |
0.411 |
| CG |
0.011 |
0.016 |
0.006 |
| GG |
0.556 |
0.577 |
0.580 |
| GA |
0.000 |
0.000 |
0.003 |
| Overall LD p value | <0.00001 | <0.00001 | <0.00001 |
LD – linkage disequilibrium.
For all comparisons of overall haplotype distribution between the groups: p > 0.05.