Table 5.
Comparison of Diagnostic Results of NAB alone and NAB combined with Tumor Markers according to tumor stage
| Diagnostic Method | Sensitivity (%) | Specificity (%) | Accuracy (%) | PPV (%) | NPV (%) |
|---|---|---|---|---|---|
|
Early Stage (Stage 1 and 2, n=55) | |||||
|
NAB alone |
75.9 |
100 |
88.1 |
100 |
80.9 |
|
NAB+Serum Tumor marker |
|
|
|
|
|
| CYFRA (3.3) |
77.8 |
81.8 |
79.8 |
80.8 |
78.9 |
| CEA (5) |
75.9 |
90.9 |
83.5 |
89.1 |
79.4 |
| SCC (2) |
75.9 |
92.7 |
84.4 |
91.1 |
79.7 |
|
NAB+Cytological Tumor marker |
|
|
|
|
|
| CYFRA (15.7) |
94.4 |
98.2 |
96.3 |
98.1 |
94.7 |
| CEA (0.6) |
87 |
92.7 |
89.9 |
92.2 |
87.9 |
| SCC (0.86) |
87 |
70.9 |
78.9 |
74.6 |
84.8 |
|
Advanced Stage (Stage 3 and 4, n=84) | |||||
|
NAB alone |
88.1 |
100 |
92.8 |
100 |
84.6 |
|
NAB+Serum Tumor marker |
|
|
|
|
|
| CYFRA (3.3) |
90.5 |
81.8 |
87.1 |
88.4 |
84.9 |
| CEA (5) |
92.9 |
90.9 |
92.1 |
94 |
89.3 |
| SCC (2) |
89.3 |
92.7 |
90.6 |
94.9 |
85 |
|
NAB+Cytological Tumor marker |
|
|
|
|
|
| CYFRA (15.7) |
95.2 |
98.2 |
96.4 |
98.8 |
93.1 |
| CEA (0.6) |
95.2 |
92.7 |
94.2 |
95.2 |
92.7 |
| SCC (0.86) | 94 | 70.9 | 84.9 | 83.2 | 88.6 |
Note-Numbers in parentheses are cut-off levels of tumor markers in ng/mL.
Abbreviations: PPV, positive predictive value; NPV, negative predictive value; CEA, carcinoembryonic antigen; SCC, squamous cell carcinoma; CYFRA, cytokeratin 19 fragments; NAB, needle aspiration biopsy.