Table 2.

Regulation of key metabolic pathways in guinea pig lungs infected with M. tuberculosis

Pathway	Up	Down
Oxidative Phosphorylation	NDUFA12, NDUFV1, UQCRC2, SDHB, NDUFAB1, ATP5C1, PPA1, ATP6V0E1, ATP5J, NDUFB8, ATP5A1, NDUFA7, COX5A, LHPP, UQCRC1, ATP5G3, NDUFA11, ATP5J2, NDUFV3, NDUFV2, NDUFS6, NDUFS8, NDUFS3, ATP6V1D, COX5B, COX6A2, COX4I1, ATP6V1F, ATP6V0D1, COX7A2L, ATP6V0C, ATP6V1E1, ATP6V0B, ATP6V1B2, NDUFB4, NDUFB2, NDUFA3, COX17	ATP5O, ATP5F1, ATP12A, NDUFB5, NDUFB7, NDUFA4
Glycolysis/Gluconeogenesis	LDHA, ENO1, HK1, ADH5, TPI1, GAPDH, ADH1A, AKR1A1, ALDOA, PGK2, ENO3, GPI	ALDOC, DLAT, PFKL
TCA cycle	FH, SDHB, PC, MDH2, IDH1, ACO2, SUCLG1	DLAT
Lipid, Glycerolipid and Glycerophospholipid metabolism	ABHD2, ABHD8, ACSL5, ADH1A, ADH5, AGPAT2, AKR1A1, CPT2, CEPT1, CYP27A1, CYP2B18A, CYP26B1, DGKA, FDPS, GCDH, HADHA, HADHB, LPL, PLA2G2A, PGS1	AGPAT1, AGPAT3, ACSL1, CPT1B, CYP2F1, CYP2A13, CYP1A2, CYP11A1, CYP2D40, PLD2, PPAP2A, PLA2G2C, PLA2G5, PAFAH1B1, PNPLA3, PTDSS2, LPGAT1
Purine and Pyrimidine metabolism	ADSS, NT5C2, NPR2, AK2, XDH, ADCY4, POLR2E, HPRT1, PRP, DPYD, TXNRD2, NT5C2, CAD	AK1, DCTD, POLA1, POLR2F, POLR2K, PRPS1L1, GUK1, PDE6G, PDE6A, POLR3GL, ENPP1, ZNRD1, PRUNE, TYMS, TK1
Amino acid metabolism	GLUL, GCDH, HADHA, HADHB, PLOD3, TMLHE, SETD1A, SETD8, HSD17B10, IVD, LDHA, MIF, PRDX6	ALDH4A1, ALDH6A1, ASS1, AMT, AGXT, AGMAT, ABAT, AHCYL1, CYP1A2, CKB, DNMT1, DBT, DDC, GLS, GLUD1, GLDC, GNMT, HMGCS1, NOS1, MAT2A, ODC1, WHSC1L1, SUV420H2, SUV420H1