Table 3.

Regulation of key signaling pathways in guinea pig lungs infected with M. tuberculosis

Pathway	Up	Down
MAPK	MRAS, MAPK7, RAC1, TGFB1, MAPKAPK5, MAPKAPK2, FGFR3, IL1B, PLA2G2A, RAC2, RAP1B, SOS2, MAPK8IP3, RRAS, HSPB1, CACNA1E, ARRB2, MAP2K2, FGF17, STK4, SRF, PAK2	MEF2C, CACNB2, CACNB4, TAOK3, CACNG4, DUSP9, FGFR4, PPP5C, FGFR2, FGFR1, RAP1A, CACNA1C, FOS, TNF, RPS6KA1, TGFB3, PPM1A, FGF19, ATF4, AKT3, CRKL, MAPK11, FGF8, MAPK1, FGF2, TP53, PPP3CB, MAPK8IP2, FGF12, FGF10, MAP3K4, PLA2G2C, PLA2G5, PRKACG, PRKACA, CHUK, PTPRR, RASA1, CACNA1S, BRAF, MAP2K6, MAP2K1, DUSP2, DUSP4, RASGRP2
Wnt	RAC1, CUL1, CSNK2A2, PPP2R1A, RAC2, CSNK1A1, PPP2CA, RHOA, PSEN1	PRICKLE1, CSNK1E, LRP5, PLCB3, EP300, TBL1XR1, CTBP1, WNT3, CAMK2G, CAMK2A, CCND1, NKD2, SMAD4, SMAD2, PPP2R5D, TP53, PPP3CB, CSNK2A1, CTNNB1, PRKACG, PRKACA, CAMK2D, LEF1, WNT10A, FBXW11, BTRC, FZD9, FZD3, TCF7L2
Calcium	VDAC1, ERBB2, ATP2A1, GNAQ, TNNC1, CACNA1E, P2RX2, ADCY4, SLC25A6	PLCB3, ADRA1B, PHKG2, CACNA1C, ADORA2A, CAMK2G, CAMK2A, GNAS, PLN, HTR6, NOS1, RYR1, VDAC2, PPP3CB, SLC8A1, CYSLTR1, P2RX1, CALM2, ATP2B4, ATP2A3, PRKACG, PRKACA, CAMK2D, LTB4R2, CACNA1S, ADRB2, PLCG1