Table 4.

Regulation of key immune response related genes in guinea pig lungs infected with M. tuberculosis

Pathway	Up	Down
Chemokine signaling pathway	GNB4, RAC1, IL8, GNG5, HCK, RAC2, FOXO3, RAP1B, SOS2, ADRBK1, NCF1, GNAI2, CCL27, VAV3, RHOA, ADCY4, ARRB2, NFKBIB	GNB1, PLCB3, CCL5, CXCL9, RAP1A, CXCR3, GNG8, GNG2, CCL21, AKT3, CRKL, MAPK1, PRKACG, PRKACA, CHUK, CCL11, BRAF, MAP2K1, RASGRP2
Cell adhesion molecules (CAMs)	HLA-DQB1, ITGB7, HLA-A, HLA-B, HLA-B, HLA-DMA, NRXN2, HLA-DPA1, HLA-DRB1, HLA-DRB1, ALCAM, CLDN18, CLDN14	MPZL1, HLA-E, HLA-F, CADM3, CADM1, CD34, CD8A, CD99, CDH3, CLDN4, CLDN6, NCAM1, GLG1, NLGN2, ITGB2, ITGB8, ITGA9, CNTNAP1, SIGLEC1
Cytokine-cytokine receptor interaction	IL1, RAP, IL8, TGFB1, IL1B, CSF1R, IL23A, BMP8A, CCL27, BMP4, BMPR2	GHR, CCL5, CD70, CXCL9, KIT, CD27, CXCR3, TNFα, IL2RG, CNTFR, BMPR1A, IL23R, CCL21, TGFB3, FLT4, BMP5, IFNGR2, LTA, IL9, CCL11, TNFSF10, ACVR2A
Leukocyte trans-endothelial migration	RAC1, CYBA, CYBB, RAC2, RAP1B, ACTG1, NCF1, GNAI2, EZR, ACTN4, VAV3, RHOA, PTPN11, CLDN18, CLDN14, ACTB	RAP1A, CD99, RHOH, THY1, MAPK11, CTNNB1, CLDN4, CLDN6, ITGB2, MLLT4, PLCG1
Natural killer cell mediated cytotoxicity	RAC1, ARAF, HLA-A, HLA-B, RAC2, SOS2, VAV3, LAT, FCER1G, PTPN11, MAP2K2, PTPN6	TYROBP, HLA-E, HLA-F, TNF, IFNGR2, MAPK1, PPP3CB, GZMB, ITGB2, TNFSF10, BRAF, MAP2K1, PLCG1
T cell receptor signaling pathway	SOS2, GRAP2, VAV3, LAT, RHOA, NFKBIB, MAP2K2, PTPN6, PAK2	CD8A, FOS, TNF, NCK1, AKT3, MAPK11, MAPK1, PPP3CB, CHUK, MAP2K1, PLCG1
B cell receptor signaling pathway	RAC1, RAC2, SOS2, CD81, VAV3, LILRB3, NFKBIB, MAP2K2, PTPN6, CR2	FOS, AKT3, MAPK1, PPP3CB, CHUK, MAP2K1
Antigen processing and presentation	HLA-DQB1, HLA-A, HLA-B, HLA-B, CD74, HLA-DMA, HLA-DPA1, HLA-DRB1, HLA-DRB1, HSP90AB1, CTSB, CTSS, HSP90AA1	HLA-E, HLA-F, CD8A, TNF, TAPBP, HSPA5, PSME2
Complement and coagulation cascades	C4A, C3, C1S, SERPING1, CR2	CD55, MASP2, KNG1, SERPINC1, F8, C9, C6, C3AR1, C5AR1