Table 1.
Potential targets predicted by EMA based on flux correlation
| No. | Enzyme | EC No. | Gene | Vσ |
|---|---|---|---|---|
| R43 |
lactate dehydrogenase |
EC-1.1.1.27 |
ldh |
2.76 |
| R22 |
pyruvate dehydrogenase complex |
EC-1.2.1.51 |
pdhABCD |
1.65 |
| R59 |
acetolactate synthase |
EC-4.1.3.18 |
alsS |
0.70 |
| R60 |
ketol-acid reductoisomerase |
EC-1.1.1.86 |
ilvC |
0.70 |
| R61 |
dihydroxy-acid dehydratase |
EC-4.2.1.9 |
ilvD |
0.70 |
| R53 |
transhydrogenase |
- |
- |
0.57 |
| R36 |
transketolase |
EC-2.2.1.1 |
tkt |
0.45 |
| R37 |
transaldolase |
EC-2.2.1.2 |
ywjH |
0.44 |
| R31 |
glucose 6-phosphate dehydrogenase |
EC-1.1.1.49 |
zwf |
0.39 |
| R32 |
6-phosphogluconolactonase |
EC-3.1.1.31 |
ykgB |
0.39 |
| R33 |
phosphogluconate dehydrogenase |
EC-1.1.1.44 |
yqjI |
0.39 |
| R20 | pyruvate kinase | EC-2.7.1.40 | pyk | 0.35 |
Detailed reactions are listed in Additional file 1, Table S1.