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Increased cell death (apoptosis) in Cdk2ap2tr/tr mESCs. (A) Extensive cell death was observed in the EBs derived from Cdk2ap2tr/tr mESCs. The DNA-laddering assay for apoptosis showed an increase in fragmented DNA in the Cdk2ap2tr/tr EBs compared to the Wt EBs. (B) Immunofluorescent analysis was performed for Annexin V in Wt and Cdk2ap2tr/tr mESC EBs. The Cdk2ap2tr/tr EBs had greater Annexin V levels and an altered EB morphology, suggesting an increase in apoptosis.
