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. Author manuscript; available in PMC: 2013 Oct 12.
Published in final edited form as: Cell. 2012 Oct 12;151(2):427–439. doi: 10.1016/j.cell.2012.09.011

Figure 6. Inhibiting cholinergic neuron activity mimics smn mutant phenotypes.

Figure 6

A. Representative traces recorded from the NMJ of control or UAS-human Kir2.1 or UASPLTXII expressed in cholinergic neurons with Cha-Gal4. Inhibiting cholinergic neuron excitability with Kir2.1 or neurotransmitter release with PLTXII increases motor neuron NMJ eEPSP amplitude. B. Expression of Kir2.1 or PLTX in cholinergic neurons disrupts rhythmic motor activity. C–F. Quantification of muscle surface area (C), locomotion (D), motor rhythm (E) and NMJ eEPSP amplitude (F) normalized to controls. Expression of Kir2.1 or PLTXII in cholinergic neurons does not alter muscle size but does reduce locomotor speed, disrupt motor rhythm and increases NMJ eEPSP amplitude. Data are represented as mean +/− SEM, *=p<0.05, ***=p<0.001.