Figure 1.

Chronic dopamine depletion increased the frequency and prolonged the decay kinetics of mIPSCs. A, Representative recordings of mIPSCs in STN neurons derived from control and 6-OHDA-treated animals. The frequency but not the amplitude of mIPSCs was greater following dopamine depletion. B, Cumulative probability (cum. prob.) plots of the sample populations confirmed that dopamine depletion significantly reduced the intervals between mIPSCs but had no effect on the conductance underlying mIPSCs. C, The mean frequency of mIPSCs was significantly enhanced by dopamine depletion, whereas the mean conductance underlying mIPSCs was unaltered. D, The decay of mIPSCs was prolonged by chronic dopamine depletion, as evidenced by representative mean peak-scaled mIPSCs and box plots. *p < 0.05.