Figure 2.
Chronic dopamine depletion increased the magnitude of evoked GABAA receptor-mediated synaptic transmission but had no effect on short-term synaptic plasticity. A–H, Following chronic dopamine depletion, the magnitude of synaptic transmission evoked at 10 Hz (A–D) and 50 Hz (E–H) was enhanced with no alteration in short-term synaptic plasticity. A, E, Representative recordings. B, F, Peak and normalized conductances plotted against IPSC number. C, D, G, H, Chronic dopamine depletion significantly increased the conductances underlying IPSC1 and IPSC25 (C, G) but had no effect on the ratio of conductances underlying IPSC2 to IPSC1 or IPSC25 to IPSC1 (D, H). *p < 0.05.