Table 1.
Cardiorespiratory variables during eupneic breathing before and ~10 min after bilateral microinjections of 1 mM Bicuculline, 0.3 mM Muscimol, and vehicle solution into the cVRG.
| TT, s | TI, s | TE, s | PPA, RU | PAA, RU | MAP, mmHg | |
|---|---|---|---|---|---|---|
| BICUCULLINE (n = 5) | ||||||
| Control | 1.18 ± 0.05 | 0.39 ± 0.03 | 0.79 ± 0.08 | 0.56 ± 0.04 | 0.08 ± 0.02 | 98.9 ± 5.1 |
| 1 mM | 0.62 ± 0.06** | 0.30 ± 0.03 | 0.32 ± 0.02** | 0.44 ± 0.03 | 0.18 ± 0.04* | 98.6 ± 6.2 |
| MUSCIMOL (n = 5) | ||||||
| Control | 1.15 ± 0.05 | 0.39 ± 0.03 | 0.75 ± 0.06 | 0.58 ± 0.04 | 0.09 ± 0.02 | 99.3 ± 4.8 |
| 0.3 mM | 1.58 ± 0.09** | 0.46 ± 0.02 | 1.13 ± 0.09** | 0.56 ± 0.02 | 0* | 100.2 ± 6.6 |
| VEHICLE SOLUTION (n = 3) | ||||||
| Control | 1.17 ± 0.05 | 0.37 ± 0.02 | 0.80 ± 0.04 | 0.55 ± 0.06 | 0.07 ± 0.02 | 98.5 ± 4.9 |
| 0.9% NaCl | 1.18 ± 0.04 | 0.38 ± 0.02 | 0.79 ± 0.03 | 0.58 ± 0.04 | 0.08 ± 0.01 | 99.3 ± 4.3 |
Values are means ± SE; n, number of animals; cVRG, caudal ventral respiratory group; TT, cycle duration; TI, inspiratory time; TE, expiratory time; PPA, peak phrenic activity in relative units (RU); PAA, peak abdominal activity in relative units (RU); MAP, mean arterial blood pressure.
*
P < 0.05,
**
P < 0.005 compared with controls.